This type of cholesterol does one very important job in the gut and liver…
Story-At-a-Glance
Hey, Matt Cook here, and cholesterol has been demonized for decades now…
The result is that most men think they need to lower cholesterol.
So they take statins from the doc that lower cholesterol — but these treatments are dangerous.
And what if I told you that cholesterol can actually be a good thing?
That it can protect your gut, your liver, and your overall health as a man?
Here’s the truth about cholesterol — what doctors never mention…
—-Important Message From Isabella—-
“He made me come this way and now I’m addicted”
Hi, I’m Isabella…
And as I peeled off my skin tight dress, his fingertips began gently exploring my body…
As he started to apply the Butterfly Technique, my eyes rolled to the back of my head, and I lost control of my breathing.
My hips began to writhe, my back arched, and the muscles between my legs contracted involuntarily.
I could hear myself moan as I dug my nails deeper into his chest.
I began to buck wildly as if riding a crazed bull in the rodeo.
My moans became screams, and I was sure the neighbors could hear me from all the way down the block.
I didn’t care. I just didn’t want him to stop.
———-
Why you actually want high HDL cholesterol as a man
Cholesterol can be a confusing subject.
It is a little complicated in reality, but it seems far more complicated because of bad theories which have accumulated over the years.
In this article, I will just look at the effect of HDL cholesterol.
HDL is often called the “good” cholesterol. This is sort of true.
HDL is protective — it does good work in the body.
But at the same time, high HDL can indicate something is going wrong, or else why would it be so high?
Recent research has shown that HDL cholesterol can be produced in the gut.
There it binds to toxic bacteria — one of the greatest drains on our health.
HDL safely smuggles endotoxin through the liver — preventing it from causing liver inflammation which would lead to liver disease.
The animal experiments were carried out at Washington University School of Medicine in St Louis. The findings were published in Science.
Before these experiments it was already known that HDL is antimicrobial and anti-inflammatory.
HDL binds up bacteria.
These microbes which are bound by HDL are a major cause of inflammation as they irritate the immune system.
“High-density like the protein (HDL) is important for cholesterol metabolism and may have anti-inflammatory and antimicrobial properties.”
The liver makes a lot of HDL. But it can be made elsewhere too.
“Although HDL is mainly produced by the liver, the intestines are also a source.”
Some people theorize about different roles of HDL, depending on where that HDL is produced — but those theories have never been tested in the real world before now.
“A role for intestinal HDL distinct from that produced by the liver has not been identified.”
To find out more, the researchers carried out a number of rodent experiments.
In these experiments, they were able to tag HDL cholesterol.
Using high-tech methods, they were able to watch the movement of HDL from its inception point in the liver or in the intestines.
The researchers expected HDL to go from the intestine into the lymphatic system. But it didn’t.
Instead, intestinal HDL entered into the portal vein — the route from the digestive system into the liver.
This was a surprising finding.
“Intestinal HDL rapidly entered the portal vein, the major blood supply to the liver.”
This raised suspicions about HDL from the intestines and bacterial endotoxin.
Bacterial endotoxin is produced all through the gastrointestinal system.
When endotoxin leaves the gastrointestinal system, it causes inflammation and disease.
This is “leaky gut syndrome,” a major cause of diabetes, cardiovascular disease, and low testosterone.
Because of the route from the intestinal system through the portal vein to the liver, the liver is a main target of endotoxin-generated inflammation.
HDL cholesterol can bind endotoxin — shielding it from the immune system and preventing excessive inflammation.
The researchers suspected that the intestinal HDL may be protecting the liver against inflammatory endotoxin.
“Past studies have shown that endotoxin activates the immune system and drives significant liver pathology, including inflammation that progresses to liver fibrosis.”
HDL wraps a protective bubble around endotoxin — preventing immune system activation, inflammation, fibrosis and liver disease.
“This raised the issue of an older concept that HDL might neutralise the microbial signal that can escape the leaky gut.”
The researchers found that the intestines were actually producing a previously unknown form of HDL cholesterol.
They named this HDL3.
Those experiments showed that HDL3 is a super protective form of HDL — completely wrapping up endotoxin.
“HDL3 sequesters endotoxin so efficiently that it could not bind to immune system receptors.”
HDL3 cholesterol completely prevents endotoxin bacteria from aggravating immune cells in the liver.
Further experiments showed that this type of cholesterol can prevent liver disease in rodents — liver disease which is identical in every way to human liver disease.
“HDL3 produced by the intestines protects the liver in a variety of mouse models of liver injury that parallel clinically relevant conditions in humans.”
These liver-disease models included resection of the small bowel, excessive alcohol consumption and high-fat diets…
All major causes of liver disease are mediated by high levels of endotoxin reaching the gut unprotected.
The final major finding of this research was that this type of cholesterol (HDL 3) is present in humans.
“Samples of human portal blood confirmed enrichment with HDL3.”
It’s a fascinating series of experiments which adds a great deal more to our knowledge about cholesterol, endotoxins, and inflammatory disease.
It also serves as a reminder that while HDL can be very protective, it can also be an indicator of underlying health problems like leaky gut.
—-Important Message For Fixing a Leaky Gut at Home—-
Patching up a leaky gut this way restores good rockiness
When the gut is leaking out endotoxins all over the body… eventually these toxins get to the penis…
And when they get to the penis, they poison the blood vessels and hurt rockiness.
Fortunately, if you can patch up a leaky gut, you can get the toxins out of the penis and restore erections again pretty quickly.
But how do you patch up a leaky gut?
Here’s how I’m doing it — try this tonight
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Enterically derived high-density lipoprotein restrains liver injury through the portal vein
https://science.sciencemag.org/content/373/6553/eabe6729