The right type of coffee activates the FXR cell receptor responsible for organ regeneration
Story-At-a-Glance
Matt Cook here, and it may seem very sci-fi to talk about regenerating your organs.
But the truth is, it’s very possible to regenerate a healthy liver simply by activating a powerful cell we all have in our bodies right now…
It’s called the FXR cell receptor and it can be activated simply by drinking the right kind of coffee…
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Which types of coffee help you regenerate your liver
The idea of regenerating damaged or destroyed body parts in humans is quite controversial.
That is, with the exception of the liver.
“The liver is unique in regenerative potential, which could recover the lost mass and function after injury and resection.”
While most scientists will accept that salamanders and worms can regenerate other parts of the body (which can be accelerated by hormones or electrical impulses)…
Human regenerative capacities are usually ignored.
We know that the liver can repair itself – and if we can understand those mechanisms we may be able to reverse damage to the rest of the body.
One key area in this field of liver regeneration is something called FXR – a receptor which is key to liver regeneration.
This regenerative switch is activated by bile acids and coffee.
These animal experiments were carried out at Rutgers University and Harbin Medical University in China. The paper was published in Acta Pharmaceutica Sinica B.
The liver has the ability to regenerate in humans and many other animals – for this reason it is critical to regeneration and longevity research.
The liver carries out a surprising number of functions in the body.
So simply learning how to regenerate the liver could have major implications for a large array of health problems.
This paper brought together a lot of different animal studies looking at the mechanisms of liver regeneration.
Over the last decade, we have found that the FXR is central to lover regeneration.
FXR is a cell receptor which is activated by bile acid.
“FXR has been shown to be highly involved in liver regeneration”
In the gut, FXR activates antibiotic and healing mechanisms – and the gut is key to liver health.
Gut problems cause bacterial leakage – a problem which is dumped onto the liver.
This eventually causes liver damage.
The animal studies have shown that activating FXR also has numerous other regenerative effects on the liver…
…that is aside from lowering bacterial stress from leaky gut.
“Bile acids and FXR not only interact with each other but also regulate various downstream targets during liver regeneration.”
The more research is carried out on liver regeneration, the more important FXR activation seems to be.
“Recent findings suggest that tissue-specific FXR also contributes to liver regeneration significantly.”
FXR seems to be responsible for blood sugar control and regulation of blood lipids.
Things which are intricately tied to the gut-liver axis.
“FXR has a much broader role than regulating bile acids, cholesterol, lipid and glucose metabolism.”
In fact, these lines of research have led to enquiries by Big Pharma.
These multi billion dollar corporations want to develop treatments which can activate FXR.
Some initial studies with these types of treatments have been quite promising – but the safety and cost will be serious issues.
“These findings highlight FXR as an important ‘chemical’ target for potential use of FXR activators to regulate liver regeneration in the clinic. ”
Bile acid is the most well-known FXR activator. But supplementing bile acids can be tricky – and it’s not profitable.
I have written in my newsletters about a herb which can increase your own bile flow – thereby increasing FXR activation naturally.
But there is also a rarely discussed FXR activator found in some common beverages.
Some types of coffee contain significant amounts of a natural FXR activator called cafestol.
This could be why coffee consumption is associated with better liver health AND increased longevity.
“Liver benefits induced by coffee are accompanied by changes in the gut microbiota.”
Coffee improves gut and liver health.
The effect might in part be due to activation of FXR – a regenerative factor you will be hearing a lot more about in future!
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