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Spice it up – here’s how you can become part of the lowest cancer rate statistic without making big changes to your lifestyle.

—–Important Message——

How “shy Ryan” became fearless in the bedroom

Ryan had a few bad experiences with not getting it up, and he became very anxious about the idea of sex with a girl.

It wasn’t his fault.

Ryan discovered that in men’s brains, the hippocampus triggers anxiety in an effort to protect the organism against pain and failure.

This is VERY common with guys who have some performance problems.

And it is a crying shame. Because it’s easy to get rid of this anxiety completely, totally, and forever.

…this video (first two minutes) tells men how to get RID of performance anxiety so men are free as a bird and have wonderful feelings and memories about sex again…

This is how any man can be fearless and take any girl, anytime, by totally and forever getting RID of anxiety around sex

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This spice eliminates cancer? Proof…

As far as natural compounds go, few have enjoyed as much popularity and hype as curcumin.

A literature search yields 219,000 results for curcumin.

This is more publications in total than even for resveratrol, the over-hyped wine polyphenol that “explains” the “French Paradox.”

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So there’s quite a bit of information to go on.

Hundreds of experiments have been conducted, and dozens of review articles have been written.

But can it actually do something that no other plant molecule or chemical can?

Is there a reason to consume curcumin instead of some other spice that tastes better, like cinnamon or garlic?

Yes, I think so.

Curcumin has unique properties which make it particularly effective against colon inflammation and even colon cancer. A great many curcumin studies show this nicely.

Unlike other plant compounds that inhibit inflammation and/or cancer, curcumin has a very low absorption rate.

This allows it to reach essentially all parts of the digestive tract in high concentrations.

Most chemicals never really get there because they are absorbed long before that in the small intestine.

It’s remarkably safe.

Up to eight grams per day have been given to humans without reported side effects.

And the evidence of its effectiveness against colon cancer is strong.

It’s been found to be more effective than an equivalent dose of cisplatin, a standard chemotherapy DNA-inhibitor (which has platinum at its center, perhaps to justify its high cost).

Epidemiological evidence shows extremely low cancer rates in countries where curcumin is eaten regularly.

India, specifically, has remarkably low rates of colon cancer.

In fact, they’ve got essentially the lowest rates in the world – between 10 and 30 times lower than most countries including Japan.

In this study, Dr. Mohandas collected probably the best statistics (shown below).

I have also included data here from a different, unrelated report.

And, guess what? India is the only country where curcumin is consumed to any significant extent.

Curcumin makes up about 5% of the turmeric root.

It is usually dried, powdered, and added to cooked rice and chickpeas.

It is impossible to find white rice as part of a meal in India.

It’s always stained bright yellow with turmeric.

In India…the average intake of turmeric can be as high as 2.0–2.5 g per day…

Such is turmeric’s reputation for preventing – and sometimes even reversing – colon cancer in animal studies that the author of the study above makes special mention of it.

No other spice is even mentioned.

The low incidence of large bowel cancers in Indians can be attributed to the high intake of starch and the presence of natural antioxidants such as curcumin in Indian cooking.

The low incidence of colon cancer in India does not appear to be genetic…

The same study found that colon cancer rates among Indians actually increase when they emigrate to other countries.

But it never reaches the rates of the domestic population, probably because they bring their turmeric-eating habits with them.

This is strong circumstantial evidence for curcumin’s effects. And animal studies further this.

In 2000, researchers from Cornell, Columbia, and Rutgers published one of the best animal studies showing curcumin’s effects on cancer.

They used a popular mouse strain in which a DNA mutation results in a faulty APC protein.

This protein is necessary for microtubule growth (among other things), and creates tumors in essentially all mice that have it.

They tested four natural compounds on these mice. They pressed the compounds right into their food pellets.

Then they just then let the mice eat, stepped back, and waited – an easy study…

Curcumin at only 0.1% of the diet reduced tumors by 64%.

Quercetin and rutin did not do this even at 20 times higher concentrations.

Quercetin and rutin (especially rutin) are more absorbable and don’t reach the colon in significant amounts.

And those aren’t even all that effective against cancer anyway.

The other one they tested, CAPE (caffeic acid phenethyl ester), inhibited cancer to a great extent. But it is remarkably similar to curcumin.

The study was essentially replicated with very similar results in England in 2002.

These researchers even used the same mouse strain, ordered from the same lab. The diet was 0.2% curcumin and tumors were reduced by 39%.

However, at dietary concentrations of 0.2% and 0.5%, curcumin reduced intestinal tumor load significantly by 39% and 40%, respectively.

Lower than what the American scientists found in their study, but still good.

This could have been because the diet fed to the English mice included soy, soy oil, and whey powder.

Soybeans and soybean oil are high in polyunsaturated linoleic acid.

The isoflavones in soy are also estrogenic.

The American mice ate a diet lower in linoleic acid, which means fewer prostaglandins. (All prostaglandins are ultimately derived from linoleic acid.)

So how does it work?

The authors seem unsure…

A possible mechanism of CAPE- or curcumin-induced tumor suppression involve their antioxidant properties.

Of course, they offer up the tired old antioxidant explanation.

This explanation never holds up, because most antioxidants have only a slight effect on cancer.

And the anti-cancer effects never correlate well with the antioxidant scores.

But they offered other possible explanations.

This is one of the better ones:

Compounds that prevent tumors in APC-deficient animals, such as sulindac, aspirin, NS-398 (a COX-2 inhibitor), SC5835, curcumin, and CAPE, all reduce cyclooxygenase (COX)-2 expression…

Research consistently shows higher COX-2 activity in prostate and colon tumors.

This enzyme produces prostaglandins from linoleic acid, which has also been found to be greatly elevated in prostate cancer.

This is just one of many reasons to avoid polyunsaturated fatty acids.

Linoleic acid in particular.

Despite the moderate (not low) linoleic acid content of the Indian diet, Indians are largely protected from colon cancer.

Apparently, curcumin is the primary agent responsible for this.

Such is the reputation for curcumin in lowering both cancer and prostaglandin production, that one study undertook to investigate it in relation to both of these.

Normal rats were used in this study, and cancer was induced by feeding them azoxymethane (a standard method of inducing colon cancer in rats).

The curcumin dosage size used in this study was 0.2%.

This low dose reduced the incidence of tumors by 42%, and the total number of tumors by 56%.

Even the tumors that did form were much smaller, with a volume reduction of 57%.

Curcumin inhibited cancer to a considerable extent.

The scientists also measured the prostaglandin levels in the curcumin-fed rats and the control rats.

Prostaglandin reduction in the curcumin-fed rats was between 33% and 50%.

A low-PUFA diet would be expected to decrease this even further.

And further reductions yet can be achieved with aspirin and indomethacin.

They tested the activity of the prostaglandin-producing COX-2 enzyme.

They isolated this, added a prostaglandin precursor, and then measured the amount of prostaglandin converted (this indicates COX-2 enzyme activity).

The curcumin-fed rats produced much less of every subtype of prostaglandins when given the precursor molecule.

So, either curcumin inhibits the enzyme directly by binding to it, or it does so by down-regulating COX-2 production entirely.

Both of these possibilities have been tested.

It turns out that curcumin downregulates production of COX-2…

leading to the lower levels.

And the less COX-2 in the cells, the fewer prostaglandins created.

So it works in a more reliable manner – and in a totally different way – than straight-up inhibitors like indomethacin and aspirin.

(Although these have also been shown to inhibit colon cancer to an extent.)

Curcumin has the added benefit of being completely non-toxic.

And nearly unabsorbable.

Interestingly, curcumin fed even at up to 10% in the diet had no measurable toxic effects in the animals as compared to substituted dithiole thiones, such as oltipraz, anethole trithione, and diallyl disulfide [from garlic], which produced significant toxicity even at 0.05% in the diet.

It’s even safer than garlic – quite a bit safer, actually. You can take curcumin by the gram.

But there is yet another plausible explanation for how curcumin works.

And this is even more interesting:

This was an in vitro study, done in Petri dishes. Dr. Hanif used two different cell lines and escalating doses of curcumin.

But there’s a catch.

One of these cell lines couldn’t produce prostaglandins at all.

It was a cell line entirely lacking the enzymes necessary for prostaglandin production.

Nonetheless, curcumin inhibited growth in both cell lines…

The antiproliferative effect of curcumin in these cells, preceded by cell cycle alterations, is independent of the cells’ ability to synthesize PGs.

So, according to Hanif, prostaglandins aren’t the whole story.

Prostaglandins alone seem unable to fully describe the anticancer effects of curcumin.

He also noticed that the cells didn’t die.

They merely stopped replicating so fast.

Most cancer chemicals cause cells to basically self-destruct and explode like the Death Star at the end of the Star Wars film.

This is called apoptosis.

The cell breaks itself apart in an orchestrated manner, apparently to make room for other cells.

That curcumin fails to induce apoptosis indicates that it reduces the cell number by an exclusively or predominantly antiproliferative effect.

And the cell-cycle was shifted.

More cells were found in the G₂ phase (gap phase 2 – normal resting mode) and less in the S phase (synthesis phase).

The cells stopped dividing but didn’t die.

Growth was inhibited without killing the cell. Normalcy was achieved.

Some other chemicals can do this too.

The two graphs on the left show how curcumin can shift the cell cycle.

The two on the right show how methylglyoxal can achieve the same effect more dramatically.

There is good indication that curcumin is a glyoxalase 1 inhibitor.

Inhibiting the glyoxalase 1 enzyme raises natural methylglyoxal levels within the cell, and this powerfully inhibits cancer growth.

This is big news. And another possible explanation of curcumin’s powerful anticancer effects.

It could act by raising methylglyoxal levels.

In 2008, this study was the first to demonstrate this effect.

Dr. Santel tested curcumin on purified glyoxalase 1 and found an inhibitory concentration of 5.1 µM.

This is a low number, which means it’s a very powerful inhibitor.

Only small amounts of curcumin are necessary to inhibit glyoxalase I and raise methylglyoxal levels.

(A concentration of 5.1µM works out to only 92 curcumin molecules per one billion water molecules.)

The Dixon plot analysis revealed that enzyme inhibition by curcumin was competitive with Kᵢ= 5.1 µM.

Others have found higher values: 10.3µM (Liu, 2009), 10µM (Yuan, 2010) 12.9µM (Yamagishi, 2015).

This makes it slightly better than myricetin, another natural glyoxalase 1 inhibitor.

But lapachol and lapachone, two natural compounds found in pau d’arco bark, are even better.

Although a good inhibitor once inside the cell, the relatively large size and low solubility of curcumin mean larger concentrations must be achieved.

These concentrations can only be practically achieved in the intestine.

Studies show that even 3.6 grams of curcumin daily produces mere nanomolar concentrations in the blood.

That’s 1,000 times less than what is needed to strongly inhibit cancer there.

Not even the liver shows much of a concentration of curcumin from this massive daily dose.

But the intestinal concentration was found to be at an effective, cancer-inhibiting, and prostaglandin-inhibiting range.

So…

Curcumin is effective for inflammation and cancer in the colon…

But nowhere else.

Though inhibiting prostaglandin production in the intestines can have long-range effects.

So curcumin is definitely worth considering because of its unique behavior in the intestinal tract.

No other chemical, natural or otherwise, can safely provide this type of effect on the intestines.

——-Important Message——-

The PERFECT way to get curcumin into the body…

Here is a story from a buddy of mine:

I’ve got a few supplements here and you can see how I use curcumin along with the synergistic activity of curcumin to make it even better.

In fact, curcumin is just one of many supplements I talk about in the T Rewind protocol.

You can try the entire T Rewind protocols right now for just a single dollar.

You’ll get all the modules including the curcumin info, and how to lower harmful estrogen levels (yours may be higher than your wife’s), and how to double or TRIPLE testosterone.

Click here to try T Rewind protocol for just $1.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.