If this is happening to you, you need more B12
Story-At-a-Glance
Matt Cook here, and there’s one very obvious symptom when a man is low on vitamin B12.
Ask yourself: is this happening to me often?
And then you will know if you need to supplement with B12…
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This is one big sign that your vitamin B12 levels are too low
Migraines are a major headache for those who suffer them and for the medical establishment.
This painful and debilitating condition can be very difficult to treat.
As anyone with migraine knows, you may even get different diagnoses from different experts —
…very few people know what’s going on inside your head when you suffer from migraines.
One thing we do know is that migraines cause changes to the blood vessels inside the brain.
In the majority of cases, the blood vessels dilate — expand.
These dilating blood vessels are a probable trigger for pain and visual disturbances experienced by many (but not all) migraineurs.
Caffeine causes blood vessels to constrict — tighten up.
So if you’re one of the people whose migraines improve with coffee or tea you are probably in the majority.
One thing that causes blood vessels to dilate is a gas called nitric oxide.
This likely trigger for migraine is partially kept under control by vitamin B12.
The lower your blooming B12 levels are, the more likely you are to suffer from regular migraine.
The human research was carried out at the Tehran University School of Medical Sciences in Iran. The paper was published in the journal Headache.
Nitric oxide is one of the best leads in the chase for finding the root cause of migraine.
B12 helps to control nitric oxide.
“Vitamin B12 is thought to be involved in important pathways that seem to be related to migraine including scavenging against nitric oxide.”
The study set out to see if there were any differences and B12 levels in people who suffered migraines compared to those who didn’t.
They looked at B12 levels in the blood and also something called methylmalonic acid.
You see, sometimes B12 levels in the blood don’t tell the whole picture.
B12 is metabolised in tissues and elevated methylmalonic acid is actually a better indicator of functional B12 deficiency.
“The aim of the study was to evaluate serum vitamin B12 and methylmalonic acid status in migraine patients compared to healthy controls.”
The researchers recruited 70 people with migraine and 70 people who didn’t suffer with the condition.
They found significant differences in average B12 blood levels.
“B12 levels were found to be significantly lower in migraine patients compared to healthy subjects.”
Migraine sufferers had B12 blood levels around 510 — whereas others had B12 levels around 670.
510 is not considered a B12 deficiency.
Most doctors will only consider B12 levels below 180 to be a deficiency.
Many doctors consider anything below 400 to be suspiciously low.
But for sure, most doctors would look at 510 and so there’s no problem with vitamin B12.
Yet, B12 levels were significantly lower in people who suffer with migraine – and B12 probably plays a role in controlling nitric oxide — a probable trigger for migraine.
When the researchers compared the highest versus the lowest levels of B12 levels to look at the likelihood of having migraine…
They found those with highest levels of vitamin B12 had an 80% less chance of having migraine.
There was an even stronger link between migraine and methylmalonic acid.
Methylmalonic acid is produced in tissues and B12 helps to keep methylmalonic acid lower.
High levels of methylmalonic acid are probably a better indicator of B12 insufficiency than low levels of vitamin B12 in the blood are.
People with the highest levels of methylmalonic acid were 5 times more likely to have recurrent migraines.
“Patients in the highest quartile of methylmalonic acid had more than 5 times increased risk of having migraine.”
This overall picture indicates that there are very low levels of B12 in the tissues — even though blood levels are “normal”.
Migraines are complicated — but the research reported in this paper shows that vitamin B12 insufficiency could be one of the major factors in predisposing people to recurrent migraines.
“Participants with lower vitamin B12 and higher methylmalonic acid have higher odds of migraine.”
If you suffer from migraine I’d suggest you test both vitamin B12 and methylmalonic acid.
Insufficient B12 might just be the cause.
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Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study
https://pubmed.ncbi.nlm.nih.gov/31471907/