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True or false: Drinking just the right amount can prevent heart attacks and even stop Alzheimer’s…?
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Study: Alcohol Is Good For You…?
A number of studies have shown that small or moderate amounts of alcohol can prevent chronic disease.
Some results indicate that moderate alcohol intake lowers the risk of dementia, heart disease, and infertility.
A recent study from Brazil shows how small amounts of alcohol make the heart more resilient to stress.
This study shows that alcohol triggers changes in enzymes that could protect against heart attack damage.
Researchers at the University of São Paulo’s Biomedical Science Institute conducted these animal experiments and published the results in the Journal of Cardiovascular Research.
Heart attacks occur when blood flow to the heart decreases or stops.
Blood delivers oxygen delivers to the heart.
And if there is not enough oxygen, that eventually causes damage to the heart muscle.
Scientists can create heart-attack-like injuries in the lab by limiting the flow of blood to the heart.
They call this ischemia-reperfusion injury – and they use it in heart attack research.
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Researchers discovered that pure alcohol (ethanol) can protect the heart from ischemia-reperfusion injury (simulated heart attack).
“We previously demonstrated that acute ethanol administration protects the heart from ischemia-reperfusion (I/R) injury.”
This study looked at the effect of alcohol metabolites on the heart damage associated with heart attacks.
Acetaldehyde is a compound produced by the metabolism of alcohol in the body.
Scientists believe this is a main cause of hangovers.
“We characterized the role of acetaldehyde and its metabolizing enzyme in a model of cardiac I/R injury.”
The study showed that small amounts of alcohol protect the heart.
“Pre-treatment with alcohol reduced cardiac injury in the hearts of mice.”
Then they tested acetaldehyde (as mentioned above, your body makes that after you consume alcohol).
And acetaldehyde also protected the heart from heart-attack-induced damage.
“Pre-treatment with acetaldehyde increased ALDH2 activity and reduced cardiac injury in hearts of wild-type mice.”
ALDH2 is aldehyde dehydrogenase, an enzyme involved in detoxifying acetaldehyde.
In the study, both alcohol and acetaldehyde increased ALDH2.
Then they performed the same tests on mice without the ALDH2 enzyme…
And those mice suffered much more damage to their hearts.
“Acetaldehyde pre-treatment of hearts of ALDH2 deficient mice resulted in exacerbated injury.”
Scientists then used a drug to block ALDH2 in normal mice.
But blocking ALDH2 also prevented its protective effect – it seems that ALDH2 is protective.
“Pharmacological inhibition of ALDH2 mitigated protection.”
So the scientists concluded that low levels of acetaldehyde can protect the heart by increasing ALDH2.
You can achieve low levels of acetaldehyde through moderate alcohol intake.
“Our findings suggest that low levels of the alcohol metabolite acetaldehyde are heart protective.”
The study shows that some of this protective effect is due to an increase in the ALDH2 enzyme from alcohol/acetaldehyde.
“Our findings suggest that ALDH2 is a major regulator of cardiac acetaldehyde levels and protection from heart injury.”
Alcohol or acetaldehyde cause stress in the heart, though.
But in low amounts, they seem to strengthen the heart.
And a stronger heart deals better with the stress that comes with a heart attack.
Under stress, the heart produces large amounts of a compound called 4-HNE.
When it builds up, 4-HNE damages the heart cells.
Critically, 4-HNE is chemically similar to acetaldehyde.
Alcohol or acetaldehyde will increase ALDH2.
ALDH2 will remove not only acetaldehyde but also heart-damaging 4-HNE.
So alcohol actually increases the enzymatic clearance of 4-HNE.
This may be one reason why small amounts of alcohol are protective.
Unsurprisingly, the study did not find that higher levels of alcohol are even more protective.
“High levels of alcohol are damaging in any model of heart injury.”
Moderate amounts of alcohol seem to protect against Alzheimer’s disease too.
Studies have shown that a deficiency of ALDH2 is a risk factor for late-onset Alzheimer’s disease.
So moderate alcohol intake may protect the heart in the same way that it protects the brain.
You should always consult a healthcare professional about diagnosing and treating health problems.
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