Important for men
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Prostaglandins
Hey, Matt Cook here, and you’ve probably seen NSAIDs mentioned before — they are a class of anti-inflammatory painkillers.
They include treatments like aspirin, ibuprofen/Advil, naproxen/Aleve, Diclofenac/Voltaren, and celecoxib/Celebrex.
Aspirin is the oldest of this type of treatment, and (in most cases) it’s by far the safest.
Many people are unaware of the vast array of side effects caused by these treatments, especially the more modern ones.
Let’s look at a research paper outlining some potential problems caused by these treatments.
The review of human research was carried out at Cooch Behar Panchanan Barma University in India. This paper was published in Biochemical Pharmacology.
Prostaglandins are inflammatory substances produced in the body.
They are made from polyunsaturated fatty acids (PUFAs) – fats that mostly come from vegetable oils.
The body produces prostaglandins from vegetable oils through COX enzymes.
NSAIDs mostly work against these enzymes, so they effectively reduce pain and inflammation.
“Owing to the efficacy in reducing pain and inflammation, NSAIDs are amongst the most popularly used medicines on the WHO’s Model List of Essential Medicines.”
The consumption of these treatments is increasing. This has been blamed on aging populations, sedentary lifestyles, and increasing rates of global obesity.
I would also add the ever-increasing consumption of polyunsaturated fats from vegetable oils to this list of causes of musculoskeletal complications.
“With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable.”
According to a report by the World Health Organization published in The Lancet in 2018, nearly 1 in 4 globally suffers from a musculoskeletal problem.
NSAIDs can have profound effects on the cardiovascular system.
Many are marketed as having beneficial effects against cardiovascular problems and cancer…
…although except for aspirin, more recent evidence indicates the contrary.
“Apart from analgesic, anti-inflammatory, and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks.”
Most of these treatments have a spectacularly long list of often serious side effects.
“However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral, and pulmonary complications.”
The gastrointestinal side effects include stomach and duodenal ulcers, bleeding (sometimes severe), and gastrointestinal perforation.
These are often listed side effects of aspirin, but it’s easy to avoid these issues with aspirin, and other NSAIDs are more likely to cause these problems.
Cardiovascular issues include an increased risk of heart attack, stroke, and hypertension.
Again, aspirin is an outlier here because it decreases the risk of these issues.
Many NSAIDs are also liver toxic, causing inflammation and injury, which can lead to liver failure.
These treatments can impair kidney function and lead to acute or chronic kidney injury.
They can also cause fluid retention, amplifying conditions like heart failure and high blood pressure.
Long-term studies show that these medications (except aspirin) may cause cognitive decline.
NSAIDs can also trigger asthma-like conditions in susceptible people.
“The present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage.”
And all that’s not to say you should never take one of these treatments.
But the risks of these treatments are often completely overlooked by patients and doctors.
“The review does not intend to vilify these ‘wonder treatments’; rather provides a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration.”
These are not harmless substances. If you consider taking one, you should consider the potential cost.
The risk of long-term use of these treatments is high, and there are always safer long-term solutions.
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