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This could be the culprit behind arthritis and joint pain – and new research reveals how to make that pain and discomfort disappear…
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Oligofructose and stopping joint pain
Osteoarthritis is a common joint disease that results in the breakdown of cartilage and bone.
Osteoarthritis is painful and it can destroy fingers, knees, and hips. It’s more common in obese and overweight people.
A new study shows that obesity and osteoarthritis may have the same cause.
We now know that gut bacteria cause osteoarthritis.
In these experiments, scientists prevented osteoarthritis with a dietary supplement found in plants.
Researchers at the University of Rochester Medical Centre conducted these experiments and published their results in the journal of the American Society for Clinical Investigation (JCI Insight).
Obesity and osteoarthritis – we now know that systemic inflammation drives both conditions.
The cause of this inflammation is bacteria leaking from the gut and inflaming all tissues in the body.
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“The impact of obesity on osteoarthritis is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis.”
But one type of bacteria is strongly associated with healthy gut function. Bifidobacteria seems to keep the gut barrier intact – preventing leakage of inflammatory bacteria.
In this study, the researchers fed some rodents a very high-fat diet.
This particular diet causes obesity in rodents.
And it turned out that the high-fat diet also led to a decrease in protective Bifidobacteria.
The high-fat diet led to obesity and an explosion of inflammatory bacteria species.
“Obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance.”
The increase in inflammatory bacteria also led to white blood cells attacking the joints of the lab animals.
“An effect of this systemic inflammation culminates with accelerated white blood cell migration to the joint membrane and accelerated knee osteoarthritis.”
The high-fat diet changed the rodents’ gut bacteria…
And this triggered the immune system to attack the joints of the animals.
The scientists then supplemented the obese and arthritic animals with oligofructose.
That’s a form of dietary fiber in which molecules of sugar are bound together – similar to starch.
You can get oligofructose in bananas, onions, chicory, and asparagus.
And one of the highest dietary sources of oligofructose is the Jerusalem artichoke.
“After 12 weeks, these diets were supplemented with the indigestible prebiotic fiber oligofructose.”
The scientists found that supplementation with oligofructose also changed the gut bacteria in the rodents.
Oligofructose can reverse some of the damage caused by a high-fat diet.
Humans can’t actually digest oligofructose…
But it can feed healthy gut bacteria.
The scientists in this study believe it allows healthy bacteria to survive the high-fat diet.
“Oligofructose tended to reverse key changes induced by obesity.”
It only took a couple of weeks for the supplement to improve the health of the gut bacteria in the experimental animals.
“The gut microbiome of obese and lean mice was stably distinct throughout the experiment, with oligofructose permanently shifting diversity of both groups within 2 weeks.”
Oligofructose improves the health of gut bacteria.
“Oligofructose converts the obese gut microbiome to a lean diversity profile.”
The supplement massively increased the levels of protective bacteria in the animals.
“Oligofructose raised the abundance levels of Bifidobacterium species more than 1,000-fold.”
Supplementing with oligofructose reduced the degree of immune systems attack on the animals’ joints – slowing the progression of osteoarthritis.
“Obesity-associated white blood cell migration to the synovium is reduced in oligofructose supplemented mice.”
The experiment also showed that oligofructose can protect cartilage from destruction.
Cartilage is a vital part of the structure of joints.
“Oligofructose prevents cartilage loss in the osteoarthritis of obesity.”
Supplemental oligofructose protected against all of the degenerative aspects of osteoarthritis – incredible results.
“Oligofructose rescued cartilage, joint inflammation, chondrocyte hypertrophy, osteophyte formation, and mineralization of the meniscus.”
The supplemental intervention protected the animals from osteoarthritis…
…even though they were eating the same diet that caused their osteoarthritis.
(Unfortunately, It did not also cure obesity.)
“This protection was evident despite continued consumption of the high-fat diet and persistence of obesity.”
The study proves that altering gut bacteria can treat osteoarthritis.
“Oligofructose supplementation is associated with reduced inflammation in the colon, circulation, and knee – and protection from osteoarthritis.”
Oligofructose is prebiotic.
This means it promotes certain types of bacteria.
Different people have different bacterial colonies in their gut, so some prebiotics can be a problem for some individuals.
If you are experimenting with prebiotic substances always try a low dose first.
That’s because there is always the risk of a bad reaction.
You should see a healthcare professional about diagnosing and treating osteoarthritis.
—–Important Message—–
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https://insight.jci.org/articles/view/95997
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