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Story-At-a-Glance
Matt Cook here, and chemists have just created a brand new form of vitamin B1…
…also known as thiamine…
They’re calling it benfotiamine and it’s taking the world by storm.
Should you take it? Here’s what you need to know…
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New supplement taking men by storm – Benfotiamine
Diabetic neuropathy is a distracting and often painful condition suffered by many millions of people.
It can be difficult to get safe medical help for this problem.
A few lines of evidence indicate that low energy supply to the affected areas can play a major role in this problem.
Vitamin B1 — also known as thiamine — is one of the most important energy boosting substances.
A minor problem with thiamine is that it can be difficult to get sufficient amounts into certain parts of the body under stressful conditions.
To get around this problem, chemists created a new form of the vitamin called benfotiamine.
Benfotiamine delivers thiamine to regions of the body which are difficult to reach with the basic form of the vitamin.
Research is now showing that adequate doses of benfotiamine can have remarkable effects of painful diabetic neuropathy.
The human research was carried out at John’s Hospital in Budapest Hungary.
The report was published in the journal Arzneimittelforschung — which is German for Treatment Research.
Prior research has shown that thiamine may be helpful for diabetic neuropathy.
This study was designed to see the effect of different doses of benfotiamine on diabetic neuropathy symptoms.
Benfotiamine is simply a molecule which delivers pure vitamin B1 to tough-to-reach areas of the body.
The researchers recruited 36 people with diabetic neuropathy for their experiments.
The participants were aged between 40 and 70 years old.
The participants were split into 3 different groups.
The 3 groups were given different doses of benfotiamine to take every day.
The one group received 150mg. One group received 240mg.
And the final group received 320mg of benfotiamine per day.
“In a 6-week clinical trial, 36 patients (aged 40 to 70 yrs) were randomly assigned to three groups, each of them comprising 12 participants.”
All of the participants were investigated for specific symptoms of diabetic neuropathy — and the degree of those symptoms.
The investigation of diabetic neuropathy was carried out before and after the six-week benfotiamine supplementation period.
That examination was also carried out halfway through the supplementation period.
“Neuropathy was assessed by pain sensation, vibration sensation and current perceptual threshold on the peroneal nerve at different frequencies.”
All of the groups experienced improvement in their neuropathy symptoms.
“An overall beneficial therapeutic effect neuropathy status was observed in all 3 groups during the study.”
The improvements were already statistically significant at the first examination after starting taking benfotiamine — after only 3 weeks of supplementation.
“Significant improvement in most parameters appeared by week 3 of therapy.”
Benfotiamine is a relatively new supplement — and standard recommendations are usually to take 50mg per day.
This study found increasing benefits with increasing doses of benfotiamine.
The greatest improvement in diabetic neuropathy was seen in the high-dose group who are taking 320mg per day.
“The greatest change occurred in the group of patients receiving high doses of benfotiamine.”
Those folks had significantly more improvement than even people taking 240mg of benfotiamine per day.
“Benfotiamine is most effective in large doses, although even smaller daily doses it is effective at reducing painful diabetic neuropathy symptoms.”
The only real downside of benfotiamine that we know of is the cost — it’s relatively expensive because it is a new designer supplement.
The basic vitamin — thiamine — is extremely safe even at very high doses.
And some research indicates that very high doses of thiamine can be enough to treat symptoms like neuropathy.
The basic dose of benfotiamine (50mg) is not enough to achieve the maximum benefit on peripheral neuropathy symptoms.
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Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy
https://pubmed.ncbi.nlm.nih.gov/10219465/