Men taking this are 5x more likely to suffer heart failure

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Men taking this are 5x more likely to suffer heart failure

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Proton pump inhibitors are a group of treatments which are used to reduce stomach acid.

These treatments have become commonly used for dyspepsia, peptic ulcer, Gerd, Barrett’s esophagus, and other conditions.

But their use has been dogged by controversy.

These treatments are far more harmful than the previous classes of treatments used to treat these same conditions.

For example, they are linked to a significantly increased risk of heart failure and death in people with coronary artery disease.

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The human research was carried out at IIS-Fundación Jiménez Díaz in Madrid, Spain. This paper was published in PLoS One.

The authors of this study were interested in the relationship between proton pump inhibitor use and cardiovascular events in people with existing coronary artery disease.

The researchers analyzed data from over 700 patients in this study.

“Proton-pump inhibitors (PPIs) seem to increase the incidence of cardiovascular events in patients with coronary artery disease, mainly in those using clopidogrel.”

They looked at the relationship between the use of proton pump inhibitors and a number of cardiovascular outcomes.

“We analyzed the impact of PPIs on the prognosis of patients with stable coronary artery disease.”

They looked at the incidence of stroke, ischaemic attack, and heart failure or death.

“Outcomes were 1) acute ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and 2) heart failure or death.”

The patients taking proton pump inhibitors were a little older on average. They also had a higher incidence of stroke in the past.

“Patients on PPIs were older and had a more frequent history of stroke (4.9% vs. 1.1%) than those from the non-PPI group.”

Otherwise, there were no significant differences between people taking proton pump inhibitors and those not taking treatments at the outset.

“PPI users presented no differences in any other clinical variable, including cardiovascular risk factors, ejection fraction, and clopidogrel or aspirin use.”

All of the participants were followed for an average period of more than two years.

More than 10% of the participants experienced 1 of the events which were outlined as primary outcomes tracked by the study…

Events like stroke and heart failure which were.

“Seventy-eight patients met the primary outcome, 53 developed acute ischaemic events, and 33 heart failure or death.”

People taking proton pump inhibitors were more than twice as likely to experience 1 of these events – stroke, ischaemic attack, heart failure or death.

“PPI use was an independent predictor of the primary outcome [hazard ratio 2.3], along with hypertension, body-mass index, glomerular filtration rate, atrial fibrillation, and nitrate use.”

When they looked further they found that most of the risk was due to a massive increased risk of heart failure or death.

Those taking proton pump inhibitors were 5 times more likely to be diagnosed with heart failure or die during the 2 yr follow-up period.

“PPI use was also an independent predictor of heart failure/death [HR = 5.7], but not of acute ischaemic events. A propensity score showed similar results.”

This risk was independent of the other factors including high blood pressure, high BMI, atrial fibrillation, and kidney issues.

“In patients with coronary artery disease, PPI use is independently associated with an increased incidence of heart failure and death but not with a high rate of acute ischaemic events.”

The researchers called for further research into this potentially serious issue.

However, there are numerous other papers which have been published showing increased risks of fatal conditions in people taking proton pump inhibitors.

“Further studies are needed to confirm these findings.”

It really is best to find and solve the underlying issues of the gastrointestinal problems which these treatments are used to mask.

Before the widespread rollout of proton pump inhibitors, we used antacids and certain antihistamines to deal with the symptoms.

Those treatments may have problems, but they seem to be far safer than proton pump inhibitors.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Use of Proton-Pump Inhibitors Predicts Heart Failure and Death in Patients with Coronary Artery Diseasehttps://pubmed.ncbi.nlm.nih.gov/28103324/