Low levels of this manly hormone causing crippling depression in men

Make sure you are getting enough of this critical male hormone 

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Story-At-a-Glance

Matt Cook here, and there’s one important manly hormone that has been misunderstood for some time now…

Some doctors say to lower it. Others say it causes baldness and prostate problems.

But the truth is, it’s critical for men to have in the right amounts.

Without it, depression and suicide rates more than double!

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Low levels of this manly hormone causing crippling depression in men

DHT is one of the most important male hormones.

Alongside testosterone, it is responsible for many masculine traits and characteristics — both physical and mental.

These hormones are absolutely essential for men’s health.

But in the last couple of decades, DHT has been wrongly blamed for a number of common health problems — primarily baldness and enlarged prostate.

Due to these errors, many men have been given treatments which block the production of DHT.

These treatments are treatments — including finasteride/propecia and dutasteride.

Side effects of lowering DHT with these substances include erections problems, loss of sex drive, infertility and the growth of man boobs.

They can also have profound psychological effects. These treatments almost double the risk of depression.

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The human research was carried out at Western University in Ontario, Canada. The findings were published in JAMA Internal Medicine.

There have been many case reports of mood disorders relating to the use of DHT-lowering treatments called 5-ar inhibitors. 

These treatments are used for baldness and enlarged prostate.

This study was designed to find out whether there was any increase in depression in men taking these treatments to treat prostate issues.

“Is the use of 5-ar inhibitors for the treatment of benign prostatic hyperplasia associated with a risk of depression?”

The researchers analyzed data from over 90,000 men who are over the age of 66 and who had begun taking a 5-ar inhibitor because they had prostate issues.

These men were compared to a similar group of men who were not taking these treatments.

Risk of depression increased by 94% in the first 18 months after starting to take the treatments.

“Depression risk was elevated during the initial 18 months after five alpha reductase inhibitor initiation.”

DHT is not just active in the prostate risk of — but it has effects all throughout the body including the brain.

It should be no surprise that lowering DHT causes depression.

The risk of depression continued to be elevated after the first 18 months — though not to as significant a degree.

Men taking these treatments were also much more likely to self-harm.

Self harm increased by 88%.

“Risk of self-harm was significantly increased during the initial 18 months after beginning ‘treatment.’”

The research looked at two of the most common DHT-lowering treatments — finasteride and dutasteride. 

Both treatments were similar in their ability to increase depression and self harm.

“The type of 5-ar inhibitor (finasteride or dutasteride) did not significantly modify the observed associations with self-harm and depression.”

Men who use these treatments are at a much higher risk of developing depression and engaging in self harm behaviors.

“The risk of self-harm and depression increased compared with unexposed men.”

The research confirms many previous reports of people suffering with mood and behavior problems after taking these treatments.

“This is in keeping with postmarketing experience and patient concerns, and discontinuation of the ‘treatment’ in these circumstances may be appropriate.”

The treatments were designed to lower DHT — the treatments rarely do one thing. 

And these treatments also change the levels of other hormones which are important for brain function and mood.

The treatments also lower a hormone called allopregnanolone

This is an often overlooked but critical hormone for positive mood affect.

Other research has shown that low levels of allopregnanolone are found in men with depression.

“Levels of the neurosteroid allopregnanolone (produced by 5ar) are lower among men with depression.”

These treatments were being used to treat benign prostate hyperplasia which causes lower urinary tract symptoms.

These are very common problems.

But there is little evidence to show that these problems are caused by DHT.

Instead, the research shows that estrogen, serotonin, and out-of-place gut bacteria are the main factors causing prostate problems.

It is much safer and far more effective to deal with the actual causes of prostate inflammation and swelling.

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———-


Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.

 

Association of Suicidality and Depression With 5α-Reductase Inhibitors

https://pubmed.ncbi.nlm.nih.gov/28319231/