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Is this metal making men’s brains and bodies decades older?
Many people have long-term negative health effects relating to previous traumatic brain injury – mostly from sports and automotive accidents.
The long-term negative health effects of traumatic brain injury are very tricky to deal with.
And science hasn’t solved this puzzle yet.
A new study proves that traumatic brain injury has major effects on the gut.
This infers that maybe we can enhance recovery from traumatic brain injury by treating symptoms in the gastrointestinal system.
Scientists at a number of American universities conducted this animal study and published it in the journal Brain Behavior, and Autoimmunity.
In this study, researchers exposed standard lab mice to an experimental procedure that mimics traumatic brain injury.
“Moderate-level traumatic brain injury was induced in mice by controlled cortical impact.”
Then they looked at the functionality of the gut barrier in these animals.
When the gut barrier function is weak, we have problems.
Commonly, we call this “leaky gut syndrome” – a type of poisoning that occurs when bacteria from the gut leak into circulation.
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In a further experiment, researchers infect animals with bacteria to see how that affected the progression of and recovery from traumatic brain injury (TBI).
The study showed that TBI changed the structure and function of the gut – TBI caused leaky gut.
“…traumatic brain injury-induced changes in colon morphology, including increased mucosal depth and smooth muscle thickening.”
One month after the traumatic brain injury, the rodents still had leaky gut.
“At day 28, increased permeability was observed in the colon.”
Enzymes relating to brain function were elevated in the guts of experimental animals one month after traumatic brain injury.
The interplay between the gut and the brain is complex.
The mice infected with pathological bacteria during the course of the traumatic brain injury experiment had far worse outcomes.
Gut bacteria affect TBI progression and recovery.
“Bacterial infection in chronically-injured mice worsened the brain lesion injury.”
In addition, bacterial infection in the gut also led to increased brain inflammation.
“Bacterial infection in chronically-injured mice worsened the brain lesion injury and increased microglial-mediated inflammation.”
Multiple studies have shown that there are effects on the brain from the gut.
Both Alzheimer’s and Parkinson’s disease have well-known gut-related elements.
When the barrier that protects the contents of the gut from going into circulation more bacteria goes into circulation.
The increase of bacteria in circulation poisons the metabolism.
And this leads to increased inflammation and is associated with many diseases.
All stress is associated with a loss of function of the gut barrier.
Traumatic brain injury is a very potent stress.
What this study shows is not surprising – but it needed to be proven.
The relationship between brain health and gut health goes both ways.
“These experimental studies demonstrate chronic and bidirectional brain-gut interactions after traumatic brain injury, which may negatively impact late outcomes after brain injury.”
To treat TBI most effectively, we must look at this important symptom – the gut problem.
Traumatic brain injury is a vicious cycle that includes feedback from the gastrointestinal system.
TBI causes brain damage.
And this contributes to general stress. That general stress leads to a reduction in gut barrier function – leaky gut.
Leaky gut leads to an increase in bacterial inflammation in the entire organism, including the brain.
Therefore, increased inflammation caused by leaky gut is probably responsible for some of the brain problems associated with TBI.
The study provided an explanation for previous observations that point to an increase in systemic infection after TBI.
To repeat: This increase in infection rate may be due to the decreased gut barrier function.
A blow to the head leads to decreased gut barrier function, which in turn leads to further damage to the brain from bacterial inflammation.
These are early days in this field of study. But this is a good step forward in the holistic treatment of traumatic brain injury.
You should see a healthcare professional about treating and diagnosing neurological problems.
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