It protects against gingivitis and tooth loss

Story-At-a-Glance

Gingivitis is a common issue among men.

But if you don’t address it, it can turn into something much more severe…

Luckily, one simple vitamin addresses the root cause of gingivitis.

And it can do wonders for your health as a man.

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Increasing this one vitamin can save you hours in the dentist chair

Gingivitis, or the inflammation of the gums, is a very serious disease.

It may appear benign, but this inflammation of oral tissues can kickstart a variety of severe problems.

Periodontis, a more severe form of gingivitis and can lead to the loss of the tooth supporting structures.

But the problem doesn’t end there.

In 2019, a seminal review article highlighted the far-reaching consequences of oral inflammation.

“Periodontitis is an incredibly prevalent chronic inflammatory disease, which results in the destruction of tooth supporting structures. However, in addition to causing tooth and alveolar bone loss, this oral inflammatory disease has been shown to contribute to disease states and inflammatory pathology at sites distant from the oral cavity.” – Konkel et al. (2019)

Various diseases like atherosclerosis, Alzheimer’s, strokes, obesity, pulmonary infections, inflammatory bowel disease, colon cancer, and diabetes have some established links with oral inflammation. 

In effect, inflammation in the oral cavity allows certain local bacteria to pass through the givingal epithelium and into the bloodstream. 

Several factors or substances can modulate oral inflammation, including vitamin C, stress, and a variety of hormones.  

But one very common vitamin/hormone, vitamin D, appears to play a crucial role in the integrity of the oral membranes.

In a mouse model, restriction of vitamin D led to alveolar bone loss and increased inflammation in the gingiva in the mouse model. 

Topical application of vitamin D appeared to reverse the inflammatory changes:

Topical application of both vitamin D₃ and 1,25(OH)₂ D₃ to the gingiva of mice led to rapid inhibition of IL-1α expression, a prominent pro-inflammatory cytokine associated with inflammation, which also exhibited more than a 2-fold decrease from basal levels in OKF6/TERT1 cells upon 1,25(OH)₂ D₃ treatment, as determined by RNA-seq. – Menzel et al. (2019)

This is interesting considering how vitamin D also plays a crucial role in maintaining the integrity of another key membrane of the gastrointestinal system: the intestine.

“Vitamin D ensures an appropriate level of antimicrobial peptides in the mucus and maintains epithelial integrity by reinforcing intercellular junctions. Should bacteria penetrate the epithelial layer and enter the interstitium, immune sentinel cells (e.g. macrophages, dendritic cells, and innate lymphoid cells) elicit inflammation and trigger the adaptive immune response by activating Th1/Th17 cells. Vitamin D/VDR signaling in these cells ensures clearance of the bacteria. Subsequently, vitamin D also quiets the adaptive immune system by suppressing the Th1/Th17 cells and favoring Treg cells. The importance of vitamin D/VDR signaling in intestinal homeostasis is evidenced by the development of a chronic inflammatory state (e.g. IBD) when this signaling system is disrupted.” – Fakhoury et al. (2020)

Although it is an underdeveloped area of research, there are profound links between oral health and intestinal function.

Individuals with constipation or impaired transit regularly experience oral inflammation and deterioration. 

There are anecdotal reports of dentists giving their patients laxatives instead of surgical treatments, to great effect.

In summary, it appears clear that vitamin D can suppress inflammation of the gums, and oral cavity in general, while quieting the expression of cytokines. 

Considering its influence on intestinal tissues, it also seems likely that it could prevent the potential consequences of bacteria leaking from the oral cavity into the bloodstream.

Optimizing vitamin D levels remains of the utmost importance. 

A real life application could be to use vitamin D (in an oily solution, say MCT) directly on the gums. 

Monitoring levels with appropriate blood tests is essential. 

—-Important Message About Vitamin D—-

This one killer hormone is draining men of their vitamin D levels 

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…nutrients like vitamin D!

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.