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How to use DHEA to soothe painful, sore joints
Inflammatory arthritis causes stiffness, pain, and swelling of the joints.
Over the years, some researchers have noticed a relationship between hormones and inflammatory arthritic diseases like rheumatoid arthritis.
Investigations into hormones and arthritic inflammation have found that DHEAS is low in many people with these conditions.
DHEA-S is a metabolite of the hormone DHEA — it is sulfated DHEA — and DHEA is available as a supplement and it turns into DHEA-S in the body, so that may help a lot.
The researchers suggest that supplementing DHEA may lead to improvements in inflammatory arthritis.
The human research was carried out at the Johannesburg Hospital in South Africa. The results were published in the journal Arthritis Research and Therapy.
The adrenal cortex produces a number of different hormones.
Previous research had indicated that problems with the adrenal system could play a role in inflammatory arthritis.
“Decreased hypothalamic–pituitary–adrenal activity, particularly a blunted response to activation of the immune system, is strongly implicated in the onset and persistence of inflammatory arthritis.”
If true, this could play a major role in guiding treatment of these diseases.
“This phenomenon has implications with regard to the pathogenesis and treatment of the disease.”
The researchers designed a human study to learn more about the subject.
They were particularly interested in DHEAS.
DHEAS is a metabolite of DHEA — an anti-inflammatory hormone produced by the adrenal glands.
“The present study was designed to evaluate the secretion of the adrenal androgen DHEAS and its relation to clinical variables in inflammatory arthritis.”
The researchers included 87 men and women in the study. All were diagnosed with one form of inflammatory arthritis.
“87 patients, 38 with rheumatoid arthritis, 29 with spondyloarthropathy, and 20 with undifferentiated inflammatory arthritis were studied.”
The researchers also recruited almost 300 men and women without inflammatory arthritis to be used as comparison.
“Healthy women (134) and men (149) served as controls.”
Doctors took blood samples from everyone included in the study. Blood samples were tested for DHEAS and some other labs.
“Fasting blood samples were taken for determination of serum DHEAS, ESR and plasma glucose.”
The study showed that people with inflammatory arthritis have significantly lower levels of DHEAS in their blood.
“DHEAS concentrations were significantly decreased in both women and men with inflammatory arthritis.”
Over one-quarter of participants with inflammatory arthritis had DHEAS levels lower than anyone in the healthy control group.
“In 28% of patients, DHEAS levels were below the lower extreme ranges found for controls.”
DHEAS was lower in both men and women with inflammatory arthritis.
“Multiple intergroup comparisons revealed similarly decreased concentrations in each disease subset in both women and men.”
Adrenal hormones like DHEA may have a major role to play in inflammatory arthritic diseases.
“The role of hypoadrenalism in the pathophysiology of inflammatory arthritis deserves further elucidation.”
DHEAS was tested in this study — but it is a metabolite of DHEA — which is produced in the adrenal cortex.
Supplementing DHEA can increase DHEAS and both might decrease inflammation related to arthritis.
The researchers even suggested that DHEA supplementation may be useful for people with osteoarthritis and other inflammatory arthritic diseases.
“DHEA replacement may be indicated in many patients with inflammatory arthritis, even those not taking glucocorticoids.”
DHEA is a widely available over-the-counter supplement with a broad array of benefits.
One potential downside with supplementing the DHEA is that it can convert into problematic hormones like estrogen.
That’s why I take it with some progesterone, or pregnenolone, which helps steer DHEA away from the estrogen pathway.
DHEA form and dosing must be taken into account when replacing this hormone in order to avoid estrogenic side effects.
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Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis.