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—-Important Message—-
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Chiro-inositol: a breakthrough in blood sugar regulation
There are many things claimed to improve blood sugar problems on the market today, yet only a few are even worth considering.
An ideal antidiabetic compound should be safe, effective, and above all natural.
This is because type II diabetes is usually a deficiency disorder and hence, the most elegant way to treat it is by supplying the missing factors.
These missing factors are most likely magnesium, manganese, chromium, thiamine, and/or chiro-inositol.
Three of these are minerals that are often found deficient in diabetics and shown to improve the condition (i.e. Mg2+, Mn2+, Cr3+), one is a B-vitamin (thiamine), and the other is a carbohydrate of a specific type (chiro-inositol).
This antidiabetic carbohydrate happens to have a precursor called pinitol.
This is the reason why carob, which contains high amounts of pinitol (Tetik, 2011), has traditionally been known as an antidiabetic food.
Pinitol is simply an O-methylated version of chiro-inositol, a classic antidiabetic agent:
Pinitol has been shown to be a precursor of chiro-inositol in humans (Ostlund, 1998), and for this reason the two are considered nearly equivalent.
This is important to note as there are many studies on each one individually that support science on the other.
In other words, in addition to the many studies concerning chiro-inositol itself, the ones on pinitol also help to understand it.
They mutually support each other, and the fact that they’ve both been consistently shown to improve diabetes adds further weight towards their efficacy.
So what puts chiro-inositol, and by extension pinitol, in the same category as magnesium and thiamine?
Chiro-inositol happens to be an essential component of the “pH 2.0 insulin mediator” shown to activate pyruvate dehydrogenase (Larner, 1988).
It is thus part of normal insulin signalling, and since it’s a natural dietary factor not made in the body it SHOULD be considered a vitamin.
Yet due to its underappreciated role in physiology and the complexity of carbohydrate analysis — e.g. such as there being nine isomers of inositol — little is known about the chiro-inositol contents of foods.
It’s never looked for because it’s not considered essential, and difficult to do so besides.
What is known for certain is that high amounts are found in beans, alfalfa, and citrus, yet it is absent from most other fruits (Sanz, 2004).
Despite the well-supported role of chiro-inositol in insulin signalling, relatively little is written about it outside of scientific journals. Pinitol has gotten even less publicity.
So to add further weight to the evidence that chiro-inositol is an essential substance derived from food, below are a few studies concerning its precursor:
This study was published in 1987, coincidentally around the time the “insulin mediator” was discovered to contain chiro-inositol (Larner, 1988).
This study here was not inspired by any previous inositol science but was a routine investigation into Bougainvillea spectabilis, a traditional antidiabetic herb.
The researchers had the aim of discovering the herb’s antidiabetic principle, which was found to reside in the ethanol fraction upon extraction.
This was then separated further by using petroleum ether, benzene, ethyl acetate, and methanol, with the active agent partitioning into the methanol fraction.
They refined the substance further using a chromatography step and found it to be pinitol.
This had the effect of completely reversing alloxan-induced diabetes in rats at a dose of only 10 milligrams per kilogram of body weight:
It was also effective on normal rats at the same dose, although less dramatically.
This could perhaps mean that it acts through insulin, because the pancreatic β-cells of the diabetic group had been destroyed by alloxan.
They didn’t know it at the time, but this “insulin sensitizing” effect is entirely consistent with our current understanding of chiro-inositol and insulin mediator.
This potent antidiabetic compound was unambiguously determined to be pinitol by using mass spectrometry, nuclear magnetic resonance, infrared spectroscopy, specific rotation, and melting point.
Another name of pinitol is 3-O-Methyl-ᴅ-chiro-inositol.
It has been shown that pinitol after oral ingestion becomes demethylated to chiro-inositol which, in turn, would likely be incorporated into unique phospholipids on the cell membrane.
Upon stimulation by insulin, this phospholipid is selectively cleaved by phospholipase C into two components — dimyristoyl glycerol and “insulin mediator” — which are both taken up by cells (Suzuki, 1993).
The full length “insulin mediator” shown below has even been found to be as potent as insulin itself (Fonteles, 1996).
When this “insulin mediator” is released from diabetic muscle, it has been shown to contain less chiro-inositol than in the control muscle (Kennington, 1990).
This finding has been confirmed, and “insulin mediator” from diabetics also has less activity on pyruvate dehydrogenase (Asplin, 1993).
Studies conducted using American (Craig, 1994), German (Wahl, 2000), and Japanese diabetics consistently show them to excrete less chiro-inositol than controls (Suzuki, 1994).
So there’s quite a lot of data on chiro-inositol and diabetes, perhaps enough to fill a book.
Adding to this are the many clinical studies on pinitol.
There are many human trials using this as well, and they all demonstrate the same effects you’d expect from a chiro-inositol precursor:
This 2007 study marked the 30th anniversary of the first report on pinitol as an antidiabetic agent.
The study used humans instead of rats, and at twice the dose (20 mg⁄kg per day).
After 12 weeks of this simple regimen, they found that the diabetics given pinitol had 15% lower fasting blood glucose than those not given pinitol.
The treated group also had 22% lower postprandial glucose, 15% lower glycated hemoglobin, and 13% lower free fatty acids.
These results are fairly good, similar to the ones found four years earlier by the same research group (Kim, 2004):
More drastic changes were found four years later by using higher doses of pinitol.
Namely, a 28% reduction in fasting blood glucose at 1,200 milligrams per day (Kim, 2011).
These results mirror those obtained from chiro-inositol supplementation (Genazzani, 2014).
There are many such chiro-inositol studies, yet unfortunately most of them are either on animals or use it with other things, which confound the results.
Regardless: the findings lean heavily in its favor and there actually does exist a few studies that study it in isolation, and in humans.
For example, one gram of chiro-inositol per day for 6 months has been shown to reduce the HOMA index of humans by 49% (Laganá, 2014).
One half that dose, for four months, has also been shown to improve insulin sensitivity (Genazzani, 2014).
“This study demonstrated that DCI administration positively affects insulin sensitivity in obese PCOS patients and reveals that DCI is greatly effective […]” ―Genazzani, 2014
This is entirely consistent with studies using whole rats, monkeys, and human cells in vitro.
The science on chiro-inositol is well-established and consistent, with the only thing keeping it from widespread use is its natural & unpatentable status.
Pinitol and chiro-inositol appear to have a unique relationship to manganese, one of the three classic antidiabetic minerals.
A disaccharide containing pinitol and galactosamine was isolated from beef liver in a form strongly chelated with manganese (Larner, 2003).
This was found to greatly lower blood glucose in diabetic rats, and is assumed to be a metabolite of the full-length “insulin mediator.”
Consistent with this finding is that chiro-inositol, when fed to rats, acts in synergy with manganese in lowering plasma glucose (Gluck, 2010).
This could imply that, after being released from the cell membrane by insulin, some of the chiro-inositol mediators would initially chelate Mn2+ before diffusing into the cell.
Both chiro-inositol and manganese have been shown to activate protein phosphatase-2Cα independently, virtually guaranteeing they’d be more potent together.
Protein phosphatase-2Cα is responsible for activating pyruvate dehydrogenase and glycogen synthase, the two enzymes shown to be activated by “insulin mediator” over four decades ago (Jarett, 1979).
So this insulin signalling pathway has been fully worked out, despite it rarely appearing in biochemical textbooks.
Science indicates that there are actually two independent pathways of insulin signalling, one depending on chromium for activation and the other on chiro-inositol and manganese.
Thiamine is also important as it’s the cofactor of pyruvate dehydrogenase, the rate limiting enzyme in transforming glucose into energy.
Magnesium, on the other hand, has more global effects as it’s a cofactor for over 300 enzymes, either protein-bound or as the ATP-Mg2+ complex.
Diabetics have been shown to be deficient in all five of these natural dietary factors ,and every single one of them, when used individually, has been shown to improve the condition.
Science has progressed to the point that nobody should have diabetes, at all, yet the truth is sidestepped by those who profit from treating it with chemical substances.
—-Important Message for Men Who Want to Reverse and Prevent Blood Sugar Problems—-
This is why so many doctors are getting diabetes — what NOT to do
Ask yourself this — if blood sugar treatments worked, why are more and more men becoming diabetic?
Even doctors are suffering from blood sugar problems.
And it’s because of the treatments Big Pharma pushes…
My doctor dad, he took the same treatments he prescribed to his patients…
And he ended up a diabetic, and became SICKER as a result of taking these pills…
So here’s what actually works for men with blood sugar problems — and it restores potency as well
In fact, men with blood sugar problems are seeing their symptoms “melt away” with this simple tweak…
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