Christmas Eve Inflammation…

Christmas Eve Inflammation...

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Christmas Eve Inflammation…

No man wants to lose muscle.

But I’m seeing studies that show how certain types of inflammation are associated with muscle loss.

Human and animal studies show that very specific markers of inflammation (cytokines) indicate decreased muscle mass.

Now a new study shows that a very common diagnostic marker of inflammation (C- reactive protein) is predictive of age-related muscle degeneration.

It follows that decreasing inflammation somehow could be protective of muscles as people age.

These scientists based this study at Örebro University and University of Nottingham and published the results in the journal Cellular Physiology and Biochemistry.

This human study recruited over 100 women around 67 years old.

There are other studies looking at inflammation in men and animals and it seems likely that this particular study is relevant to men.

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(See the next study below for information on men to see why this is likely the case.)

Age-related muscle loss begins at about 40 years old – and people lose an average of 10% of their muscle mass per decade after 40.

The study compared a number of muscle- and strength-related measurements to blood test results for C-reactive protein.

C-reactive protein (CRP) is a marker of systemic inflammation.

It measures inflammation in general – meaning that CRP could increase due to blunt force trauma, infection, or even psychological stress.

C-reactive protein is a very common diagnostic test these days.

The study examined the relationship between C-reactive protein and muscle loss.

“The purpose of this work was to investigate the relationship between the C-reactive protein and muscle mass in elderly people.”

The study showed that muscle mass decreases as inflammation increases.

“We observed an inverse relationship between circulating C-reactive protein level and muscle mass.”

In a separate experiment done on muscle fiber samples, the team found that exposing them to C-reactive protein decreased muscle mass over a three-day period.

“We demonstrated a reduction in the size of human muscle fiber exposed to C-reactive protein for 72 hours.”

We constantly grow new muscle is grown and lose old muscle.

The amount of muscle mass retained depends on the interplay between these two factors.

The loss of muscle related to C-reactive protein was due to a decrease in muscle growth (synthesis).

“We next showed that this change was accompanied by a C-reactive-protein-mediated reduction in muscle protein fractional synthetic rate of human muscle fiber exposed to C-reactive protein for 24 hours.”

The study proved for the first time that general and systemic inflammation are clearly factors in age-related muscle loss.

“This work established for the first time mechanistic links by which chronic elevation of C-reactive protein can contribute to age-related decline in muscle function.”

A number of studies using men show that inflammation is a factor in accelerated muscle loss.

A previous study looked at some other inflammatory proteins.

These proteins (called cytokines) are more specific markers of inflammation than C-reactive protein.

The study analyzed a number of inflammatory cytokines and compared them with muscle scans and strength tests of the male and female participants.

This study also showed that inflammation is associated with decreased muscle mass and strength in aging in humans.

“Higher cytokine levels were generally associated with lower muscle mass and lower muscle strength.”

Some of the science community accepts the idea that inflammation increases with age but that this effect is not so harmful.

On the other hand, one of the strongest indicators for poor health in aging is loss of muscle mass and strength.

Since loss of muscle mass and strength are highly associated with inflammation, increased inflammation should be treated as a health risk.

“Higher cytokine levels, as often observed in healthy older persons, may contribute to the loss of muscle mass and strength that accompanies aging.”

I think it is a good idea to take a multifactorial approach to minimizing chronic inflammation.

Sudden and extreme loss of muscle mass can indicate a more serious health problem and should be assessed by a healthcare professional.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly 
https://www.karger.com/Article/FullText/484679 

Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. 
https://www.ncbi.nlm.nih.gov/pubmed/11983728 

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