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It’s been well known that there are many dangers of estrogen, the biggest being that estrogen is carcinogenic.
And it’s worse with the most powerful estrogen, estradiol.
The more estrogen you have, and the longer you have it, the more likely you are to get cancer.
You’re especially likely to get prostate cancer, but many other forms of cancer as well.
It’s leading to a movement to develop an anti-estrogen treatment for prostate cancer.
The natural hormone estradiol induces tumors in various organs of rats, mice, and hamsters
But how does estrogen cause cancer?
I think that the whole thing is now pretty clear.
As men age, their testosterone tends to fall if the man is not in great healthy.
As testosterone is declining, the men’s estrogen is rising.
It is during this process when men are most likely to get prostate cancer or another form of cancer.
In this study, researchers evaluated men who were “normal” against men who got prostate cancer.
They wanted to see any differences in their hormone and testicular functions.
The researchers also hoped they could pick up some clues as to what may cause prostate cancer.
First of all, they found:
increased estrogen synthesis in patients with prostate cancer.
The body can convert estradiol into estrone.
Estrone is more easily tested in a blood test than estradiol.
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Estrone is much, much less harmful than estradiol.
And the results of the study showed:
There was a significant age-related increase in serum estrone in the non-cancer control subjects, but not in the patients with prostate cancer.
It seems that the ability to turn estradiol in estrone is a key survival ability that can help you handle high estrogen levels.
Even men who do get prostate cancer but have a good estrone level benefit from this ability.
The study also that these men were less likely to develop a metastasized cancer if they had this skill.
But where does prostate cancer come from?
We can look at this study for a clue that prostate cancer comes from high estrogen:
This study is about human bronchial epithelial cells.
But the very same type of epithelial cells is found in the prostate and penile tissue.
Because of internal inflammation in the body, the cells start creating estrogen.
The estrogen elevates hormone secretion in the penile tissue, arteries, and lungs.
Really, every part of the body is flooded by cyclooxygenase-2 (COX-2), prostaglandin, and estrogen.
COX-2 is an enzyme that causes inflammation.
And estrogen causes extreme inflammation.
The cells respond to the estrogen by reproducing rapidly.
And that is what ends up causing prostate cancer.
It may be that soon, drugs used to treat prostate cancer will include anti-estrogen drugs for men.
So, how do you lower the chances of getting prostate cancer and other cancers?
Let’s look at key part of this inflammation chain, which is PUFAs.
If you’re new to Daily Medical Discoveries, PUFAs are polyunsaturated fatty acids.
These are a huge part of the inflammation problem.
The key to the entire prostate inflammation and cancer problem is the creation of prostaglandins.
Prostaglandins are created from PUFAs.
And having too many PUFAs in your diet dramatically increases your prostaglandin and estrogen levels.
If you eliminate PUFAs from your diet, you will have much lower prostaglandins.
Remove the PUFAs, and you remove the excess estrogen.
And eliminating PUFAs will lower your chances of getting cancer, especially prostate cancer.
You will also remove a huge cause of diabetes, high blood pressure, low metabolism, erectile dysfunction and other problems.
http://press.endocrine.org/doi/abs/10.1210/edrv.21.1.0386
Testicular and adrenocortical function in men with prostatic cancer and in healthy age-matched controls
http://onlinelibrary.wiley.com/doi/10.1046/j.1464-410X.1997.03221.x/full
17-Beta Estradiol and Hydroxyestradiols Interact via the NF-Kappa B Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells
http://toxsci.oxfordjournals.org/content/104/2/294.short
Fascinating–the “PUFAs-Prostaglandin–Inflammation-Estrogen” connection!
I’ve also read a report discussing how inflammation is a crucial factor in the progression of low grade prostate PIN cells into high grade prostate PIN cells.
Why isn’t the inflammation element in the condition being given more attention. Is it because the drug industry is already populated with anti- inflammatories and there’d be little room to develop more?
They have shown no interest in any theories that don’t lead to long term chronic illness. There are many cures out there but Big Pharma has no interest in cures. Cures are unprofitable. The inflammation model is of no interest to them.