Here’s what the science says…
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Can antibiotics mess up your memory?
I’m lucky that my memory is still reasonably sharp…
But I do have moments where I’ll walk into a room and not remember what I went in for.
This isn’t unusual, but it is frustrating.
One of the things I teach in my courses is how to lower brain inflammation (and other chronic inflammation) because that kind of inflammation directly impacts memory.
And I don’t know about you, but I want to keep my memory functioning for as long as possible.
A surprising thing that can interfere with memory is antibiotics.
These meds are miracle workers, but they have some serious downsides that are important to know about.
I also happen to think we use antibiotics entirely wrong… But that’s a subject for a different article.
Antibiotics destroy gut bacteria.
If you’ve ever taken an antibiotic and gotten “the runs” from it, then you know that they can really mess with your gut.
That’s because antibiotics can kill off bacteria in your microbiome – the stuff that keeps your gut healthy.
In this study, the scientists purposely gave mice enough antibiotics to kill off almost their entire gut microbiome.
“In the new study, the researchers gave a group of mice enough antibiotics for them to become nearly free of intestinal microbes.”
Destruction of gut bacteria led to memory problems.
There has already been some evidence of heavy antibiotic use causing problems with brain function.
But this study showed WHY it’s happening – and that it is the antibiotics that cause it.
“Compared to untreated mice, the mice who lost their healthy gut bacteria performed worse in memory tests and showed a loss of neurogenesis (new brain cells) in a section of their hippocampus that typically produces new brain cells throughout an individual’s lifetime.”
Yes, heavy antibiotic use actually caused these mice brains to STOP growing new brain cells.
“Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory.”
That sounds kind of crazy, but it’s exactly what happened.
Loss of gut bacteria lowers white blood cell count.
Here is why the researchers think the brain stopped producing new brain cells in the hippocampus…
Because the antibiotics lowered the level of white blood cells.
“At the same time that the mice experienced memory and neurogenesis loss, the research team detected a lower level of white blood cells (specifically monocytes) marked with Ly6Chi in the brain, blood, and bone marrow.”
Most of us know that white blood cells are a key function of the immune system…
But they also directly impact our brains.
The lower white blood cell count caused the memory problems.
To test this theory, the scientists used two groups of mice with low white blood cell (Ly6Chi) counts.
- Mice with genetically lower levels of white blood cells
- Mice treated with antibiotics who lost their white blood cells that way
Both types of mice displayed the same kinds of memory problems.
“In another experiment, the research team compared untreated mice to mice that had healthy gut bacteria levels but low levels of Ly6Chi – either due to genetics or due to treatment with antibodies that target Ly6Chi cells.”
“In both cases, mice with low Ly6Chi levels showed the same memory and neurogenesis deficits as mice in the other experiment who had lost gut bacteria. Furthermore, if the researchers replaced the Ly6Chi levels in mice treated with antibiotics, then memory and neurogenesis improved.”
This shows that the action of antibiotics on the white blood cells is the cause of the memory loss.
Heavy doses of antibiotics aren’t as safe as we are led to believe.
Sometimes taking heavy doses of antibiotics is unavoidable…
And they can be lifesaving. But they aren’t as safe as the medical community once thought.
Before you take antibiotics, ask your doctor if you really need them…
And don’t take them if you don’t need them, because they can cause serious memory problems – along with other issues.
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