Colon, lung, and even breast cancer have been successfully treated this way
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Blocking glutamine this way can prevent and treat cancer
A cancerous state involves many metabolic changes.
One of the foundations of cancer is uncontrolled growth and multiplication.
Any method to starve cancerous cells can slow cancer progression.
A new study shows that it may be beneficial in cancer to block the transport of the amino acid glutamine.
Glutamine isn’t harmful in itself, but it is one element that is absolutely required for the growth of cancer.
This research was carried out at Vanderbilt University Medical Center. It was published in the journal Nature Medicine.
This is one in a long series of experiments that set out to take advantage of the metabolic changes induced in cancer.
“The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for ‘treatment’ discovery in the era of precision ‘treatment.’”
The supply chain of energy and materials needed to build cancerous cells provides a potential Achilles heel in cancer.
Glutamine is an amino acid.
Amino acids are the building blocks of protein.
Glutamine in itself is not a problematic substance, in fact it has benefits in some contexts…
But glutamine is also required for some of the processes used by cancerous cells to increase their growth rate.
“The neutral amino acid glutamine serves as a key intermediate in numerous metabolic processes leveraged by cancer cells, including biosynthesis, cell signaling, and oxidative protection.”
The study did some experiments with a molecule which could block the transport of glutamine.
Blocking glutamine transport could potentially limit the growth and spread of cancer.
“We report the preclinical development of small molecules that selectively and potently target the glutamine transporter.”
The study examined the effect of this molecule in cell models and in live mice.
The study showed that the molecule which blocks glutamine transport slows the spread of cancer and increases the death of cancer cells.
“Blockade of the glutamine transporter slowed cancer cell growth and proliferation — it also increased cancer cell death.”
The glutamine blocking compound showed anti-cancer effects in cell cultures and in lab animals.
“Blockade of the glutamine transporter resulted in a number of changes which contributed to antitumor responses in cells and in animals.”
Glutamine has been a prime candidate for anti-cancer treatments for some time now — but this is the first time that this type of effect has shown.
“This is the first study to demonstrate the effect of an inhibitor of glutamine transport in oncology, laying a framework for paradigm-shifting therapies targeting cancer cell metabolism.”
There exists prior evidence indicating that the glutamine transporting protein is implicated in cancer.
The glutamine transporting protein is found to be elevated in a number of cancers, including colon cancer, breast cancer, and lung cancer.
It has also been shown that turning off the gene which produces this glutamine transporter has anti-cancer effects in cell models.
This research is in its very early stages and scientists are yet to determine what would make somebody a good candidate for a glutamine targeted cancer therapy.
The safety of this compound is yet to be proven — but this study shows (yet again) that cancer can be addressed in a metabolic fashion.
Like many diseases, even those who are said to have a genetic component, addressing metabolic problems can have significant therapeutic effects.
There are some studies in the works that would allow people to track the amount of glutamine used by certain cells with scanners…
Thereby identifying which cancers may be fought by blocking glutamine transport.
There is nothing in this study that indicates that restricting dietary glutamine would be helpful for cancer.
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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models