Important
Unsubscribe | Report as spam | Change email preferences
Bad bones from this popular treatment – do you take it?
Matt Cook here, and in my quest to help men manage mood problems, I stumbled onto serotonin modulating antidepressants…
These treatments have been marketed as affecting only the brain.
They have been positioned in such a way that many people never consider their effects on the rest of the body.
Chemical treatments are designed to target 1 specific enzyme…
…but almost every treatment targets many enzymes – something that leads to any number of “side-effects”.
And boy do these treatments have side effects!
You might be aware that most people who take these treatments end up with intimacy problems – at a minimum.
But serotonin-boosting antidepressants can have major detrimental effects throughout the body, including in the bones.
The cell research was carried out on cells at The Forsyth Institute in Boston, Massachusetts. The paper was published in the Journal of Bone and Mineral Research.
These antidepressant treatments are supposed to work by modifying the action of the serotonin transporter.
They decrease the serotonin transporter, leaving more serotonin in some regions of the brain.
“The serotonin transporter mediates antidepressant-sensitive clearance of serotonin after its release into neural synapses.”
But this serotonin transporter is a protein which doesn’t only exist in the brain.
The serotonin transporter in many different parts of the body.
And researchers discovered that the serotonin transporter is active in osteoclasts.
Osteoclasts are cells which are essential for the metabolism of bone.
They are involved in degrading bone in the natural cycle – but when altered they can cause bone problems.
“We found increased expression of the serotonin transporter in osteoclast-like cells.”
RANKL is another protein found throughout the body, and it’s shown to be particularly important for bone metabolism.
The researchers looked at the effect of this protein on human and animal cells – focusing on the roles of serotonin in osteoclast activity.
“Using RANKL stimulation we studied the possible role/s of the different components of the serotonin system in the differentiation process.”
They found that adding the antidepressant Prozac to the cultures had profound effects on the development of osteoclasts.
This is a treatment which is supposed to increase brain serotonin by affecting the serotonin transporter.
There are many reports in the literature of people taking these types of treatments having bone problems…
…and this research may have just uncovered some of the mechanisms behind that.
“Prozac, an inhibitor of the serotonin transporter, reduced osteoclast differentiation but not activation.”
The researchers found that another substance which has the opposite effect on the serotonin transporter also had opposite effects on these critical bone cells.
“Reserpine potentiates differentiation.”
This supports the idea that the primary effect of these treatments, acting on the serotonin transporter…
…may be responsible for their detrimental effects on bone mass and strength.
“These results indicate a role for the serotonin transporter in osteoclast function and suggest that commonly used antidepressive agents may affect bone mass.”
Osteoclasts are essential for bone health and osteoclasts are affected by antidepressant treatments just as brain cells are…
…because they both express the serotonin transporter protein.
“Osteoclast serotonin transporter exhibited typical serotonin uptake activity that was inhibitable by Prozac.”
The actions of serotonin in the body are quite complex, and it is damn near impossible to simply target the movement of serotonin in one specific region of the body.
Treatments which target serotonin in the brain have unwanted side effects in far-flung parts of the body.
“Reserpine inhibition of intracellular transport of serotonin induced osteoclast formation, suggesting the importance of intracellular serotonin in regulating osteoclast differentiation.”
Research in the last few decades shows that serotonin metabolism is one of the most important factors for bone health and that widely used psychiatric treatments which act on serotonin also act on the bones.
“The serotonin system plays an important role in bone homeostasis through effects on osteoclast differentiation and implies that commonly used antidepressive agents may affect bone mass.”
You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.
—-Important Message—-
This pleasure hormone works 1.8x better than testosterone
Most men think testosterone is the most important hormone for getting great male rockiness…
But the truth is, there’s something that works even better — and it also increases the amount of pleasure you feel from intimacy.
I call it the pleasure hormone, and I discovered it after stumbling onto a secret group of experts online…
All of them have been using this natural hormone to get bigger, better erections and last as long as they want…
…all while feeling pleasure ALL over their bodies, not just in their members…
And the best part? It’s fully natural. Your body already makes this hormone on its own.
———-
