Discovered on mysterious Easter Island
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Story-At-a-Glance
Hey, Matt Cook here, and imagine a compound that can increase longevity and slow aging…
A compound that can prevent cancer from ever happening…
And now imagine it can also reduce weight gain and even boost cognitive performance.
Sounds too good to be true, right?
Except that it’s real – and here’s how you can get it yourself…
—-Important Message from Wes Armstrong—-
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Mystery compound stops cancer and aging
A biological survey of Easter Island in the 1960s initially seemed like a disappointing project.
However, one of the people working on the expedition noticed that, although there were a huge number of horses on the island, there were no cases of tetanus.
Tetanus is a bacterial disease that is easily passed on from horse manure to humans.
A few years later, in 1972, a researcher analyzing soil samples taken from the island identified an unknown compound produced by bacteria.
Today we now know that unknown compound as rapamycin.
Rapamycin was the substance that inhibited the growth of tetanus on the island.
It was discovered to be a profound antifungal agent.
But its immune-suppressing effects at antifungal doses made it unusable for that purpose.
It’s now widely used to prevent organ rejection in people having organ transplants – because of its immune-suppressing effects at higher doses.
But there’s more to the story – rapamycin can also increase longevity and help to prevent cancer.
The animal experiments were performed at N.N.Petrov Research Institute of Oncology, St. Petersburg, Russia. This paper was published in Cell Cycle.
Rapamycin targets a protein/enzyme called TOR. In mammals like humans, this same substance is called mTOR.
mTOR is involved in many things, including aging.
“The nutrient-sensing TOR (target of rapamycin) pathway is involved in cellular and organismal aging.”
Early experiments showed that rapamycin could increase lifespan in small, simple, non-mammalian organisms.
For example, “Rapamycin, an inhibitor of TOR, extends lifespan in yeast and fruit flies.”
This study’s authors were curious to discover whether these antiaging effects could be extended to mammals.
On the first try, the researchers produced a 17% average increase in lifespan in mice with rapamycin.
“Lifelong administration of rapamycin extends lifespan in female mice characterized by a normal lifespan of 2 y.”
The experiments were done in female mice which reach maturity/childhood between 6 and 8 weeks.
Intermittent dosing of rapamycin began right after the rodents reached maturity.
“Importantly, rapamycin was administered intermittently (2 weeks per month) starting from the age of 2 months.”
Aside from increasing longevity, aging slowed, and unhealthy weight gain was reduced.
Rapamycin delayed the age-related incidence of cancer.
“Rapamycin inhibited age-related weight gain, decreased aging rate, increased lifespan (especially in the last survivors) and delayed spontaneous cancer.”
The researchers also raised a control group – mice treated the same way, except they were not given any rapamycin.
When all of the control group mice had died, nearly one-quarter of those taking rapamycin were still alive.
“23% of rapamycin-treated mice survived the age of death of the last mouse in the control group.”
This study, and others, show that rapamycin can have varied and profound health benefits, as well as significantly extend longevity in small mammals.
“Thus, we demonstrated for the first time in normal inbred mice that lifespan can be extended by rapamycin.”
There is currently ongoing research into the potential antiaging effect of rapamycin in larger mammals, specifically companion dogs.
These dogs live longer than rodents and have a lifestyle much more similar to that of humans.
“This opens an avenue to develop optimal doses and schedules of rapamycin as an anti-aging modality.”
Many people are already experimenting with low doses of rapamycin for antiaging and anticancer effects.
It also seems to boost cognitive performance in older folks or those with neurological conditions.
The antiaging/anticancer mechanisms of rapamycin infer that it’s likely to have an antiaging and anticancer effect in dogs and humans, as well as rodents.
There are already a growing number of people experimenting with appropriate doses of rapamycin for these potential benefits.
—-Important Message for Men About Aging—-
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