Most men don’t know that good T levels are tied to the liver
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Why this liver cleanse works so well at boosting testosterone
The liver helps to filter blood, store energy, and produce bile. It’s one of the busiest organs in the body.
In fact, the liver is responsible for over 500 different processes.
One of the often overlooked functions of the liver is regulating hormones, including testosterone.
A recent study looked at the effect of liver health on testosterone levels.
That study showed just how important liver health is for men.
The human research was carried out at the Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium. Findings were published in the Asian Journal of Andrology.
Obesity is an outward sign of liver problems.
“Obesity also often leads to nonalcoholic fatty liver disease, which covers a broad histological spectrum from simple steatosis to liver cancer.”
And obesity is also associated with low testosterone in men.
“Men with obesity regularly present with lower serum testosterone and sometimes higher estrogen compared to a healthy control population.”
The liver is known to have multiple effects on hormones. It secretes sex hormone binding globulin — a protein which binds testosterone to it.
The liver also converts some hormones to other hormones.
“Sex hormone binding globulin is secreted by the liver cells and sex steroid hormones undergo hepatic metabolization.”
This study was designed to see if there are differences in testosterone levels according to liver health.
The researchers looked at two different diagnoses for early-stage liver problems.
The milder form of liver disease is non-alcoholic fatty liver disease (NAFLD).
Over one third of Americans have non-alcoholic fatty liver disease.
The more advanced liver disease is called non-alcoholic steatohepatitis (NASH).
This affects between 3 and 12% of the adult American population.
“This study investigates whether severity of nonalcoholic fatty liver disease (NAFLD) is associated with sex steroid levels in obese men.”
The researchers recruited 80 obese men. They tested blood levels of testosterone, free testosterone, and oestradiol (a type of estrogen).
“This study included 80 obese men (age: 46 ± 11 years). Serum levels of total testosterone and estrogen were measured.”
The most accurate way to assess liver health is by taking a sample of the organ. In this study all the men had liver biopsies performed.
The liver samples were analyzed using multiple different methods. This complex liver analysis allowed for an accurate diagnosis of liver health.
“Liver biopsies were evaluated using Steatosis, Activity, and Fibrosis scoring.”
The men were split into two different groups according to the results of their liver tests.
The researchers then compared men diagnosed with NAFLD to men with the more advanced liver problem NASH.
Total testosterone levels were similar among the two groups. But there was a major difference in free testosterone.
Men with more advanced liver problems had far lower levels of free testosterone in their blood.
“Participants with steatohepatitis (advanced NASH) had lower free testosterone compared to men with only nonalcoholic fatty liver (NAFLD).”
On average, men with early-stage liver problems had free testosterone levels around 200.
Men with more advanced liver problems had average free testosterone 50 points (25%) lower.
In obese men, free testosterone levels are partially dependent on liver health.
“Among obese men with NAFLD, those with NASH have even lower free testosterone levels compared to those with only NAFLD, an association mainly driven by grade of steatosis.”
Lower free testosterone is associated with many of the chronic diseases which affect men.
The researchers also found that liver health determined the free testosterone to estrogen ratio — something recently found to have massive implications in poor rockiness.
“Participants with steatohepatitis (advanced NASH) had higher free E2/T ratios compared to men with only nonalcoholic fatty liver (NAFLD).”
This is one of the many reasons why it is important to focus on liver health.
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Did you know that good boners are tied to good liver health?
Most men are surprised when I tell them this — but I’ve found that it’s almost impossible to enjoy good, strong erections if guys have a fatty liver full of endotoxins…
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Histologically proven hepatic steatosis associates with lower testosterone levels in men with obesity.