They’re flavonoids called “hesperidin” and they can protect the brain
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These citrus fruits contain anti-Alzheimer’s compounds
Today’s newsletter reveals a startling strategy to avoid Alzheimer’s — it’s simple and doesn’t cost much and you will NEVER hear about it anywhere else.
So let me start…
…you probably know that scientific research shows that flavonoids in some fruits can protect against dementia like Alzheimer’s.
A flavonoid that’s found in citrus fruits like oranges and lemons is hesperidin.
These animal experiments were performed at the Henan University of Science and Technology in China.
The results were published in the Journal of Cellular and Molecular Neurobiology.
Energy is produced inside a cell structure called the mitochondria.
In Alzheimer’s disease, rogue electrons can damage these mitochondria.
Scientists call this rogue electron damage “oxidative stress.”
“The role of mitochondrial dysfunction and oxidative stress has been well-documented in Alzheimer’s disease.”
Damaged mitochondria in the brain can lead to insufficient brain energy.
This energetic brain drain could play a significant role in Alzheimer’s disease.
Previous studies have shown plant flavonoids may offer some protection against Alzheimer’s disease.
“Flavonoids are being utilized as neuroprotectants in the treatment of various neurological disorders, including Alzheimer’s disease.”
So this experiment was set up to see the effect of the flavonoid hesperidin on oxidative stress of brain mitochondria.
“We conducted this current study in order to explore the effects of hesperidin oxidative damage and mitochondrial dysfunction in mice.”
The study also looked at changes in the behaviours of the experimental animals.
Changes related to the development and progression of Alzheimer’s.
“Therefore, we conducted this study to explore the effects of hesperidin against Alzheimer’s induced cognitive dysfunction.”
The study took three-month-old mice.
These mice were bred to have a very high risk of developing Alzheimer’s type symptoms.
The mice were then split into 3 groups.
One group got a high dose of hesperidin.
Another group got a low dose of hesperidin.
A third group of mice did not receive any hesperidin.
“Three-month-old transgenic mice were randomly assigned to a vehicle group, or one of two hesperidin (either 50 or 100 mg/kg per day) groups.”
The animals were examined 16 weeks later.
Animals given high doses of hesperidin performed better in tests of learning and memory.
“We found that the administration of hesperidin (100 mg/kg per day) resulted in the reduction of learning and memory deficits.”
Hesperidin also led to improved locomotive function.
“Administration of hesperidin 100 mg resulted in improved locomotor activity.”
These improvements in functional Alzheimer’s tests were associated with less oxidative stress on the animals.
“Hesperidin resulted in the increase of anti-oxidative defense and mitochondrial complex I–IV enzymes activities.”
Hesperidin may help with Alzheimer’s symptoms by reducing oxidative stress in the mitochondria.
Hesperidin may allow brain cells to produce energy efficiently.
“A reduction in mitochondrial dysfunction and an increase in anti-oxidative defense, may be the reasons why hesperidin improves cognitive function.”
Hesperidin was discovered in 1828 within the peels of citrus fruits.
It is one of a number of beneficial citrus flavonoids.
Orange, tangerine, and lemon juice all have significant amounts of hesperidin.
The peel of citrus fruit has the highest amount of hesperidin.
Hesperidin survives cooking, and so marmalade is an excellent way to get hesperidin.
This study supports recent research looking at the effect of flavonoids on dementia and cognitive decline.
“Recent studies suggest that these flavonoids prevent and delay neurodegeneration in aged-population and cognitive dysfunction.”
Hesperidin is known to have anti-cancer and antiviral effects too.
“Hesperidin possesses antioxidant, anti-inflammatory, antifungal, antiviral, and anticancer activities.”
More research needs to be done into the effects of high dose hesperidin in humans with dementia.
But eating some good quality orange marmalade seems like a good idea, especially for older people.
You should consult a healthcare professional about treating and diagnosing health problems.
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