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Why I don’t take fluoroquinolones
Matt Cook here, and mutagens are things which cause mutations to the genes.
For example, ionizing radiation causes dose-dependent gene mutations that are well known to cause cancer.
But there are many other mutagens, and they can cause many other health problems aside from cancers.
Fluoroquinolones are a class of antibiotics which are known to cause a number of health problems.
Some of the problems caused by these antibiotics may be due to their mutagenic effect.
Researchers carried out experiments looking at the effect of vitamin C and vitamin E on the mutagenic effects of a fluoroquinolone antibiotic.
The results of the study show that vitamin E has a profound effect of protecting the genes against mutations.
This could protect not only against fluoroquinolone antibiotics, but also other environmental mutagens.
The cell experiments were carried out at Hospital Juárez de México, Magdalena de las Salinas, DF, México. The findings were published in BMC Pharmacology.
Mexican researchers carried out their experiments using the fluoroquinolone antibiotic norfloxacin.
Previous experiments show that it had profound mutagenicity in salmonella bacteria.
“Norfloxacin, like other fluoroquinolones, is known to be mutagenic for Salmonella bacteria.”
The mutagenicity is because of reactive oxygen species/ROS.
But there are a number of natural substances which can help to keep reactive oxygen species under control.
“This mutagenic effect is due to (ROS), because it is inhibited by some antioxidants.”
So they carried out their cell experiments to see whether antioxidant vitamins could prevent mutagenicity of this fluoroquinolone antibiotic.
“We evaluated combination therapy with norfloxacin and vitamins C and E, to reduce the possible genotoxic risk associated with fluoroquinolones.”
They carried out their experiments on the bacteria which was known to be susceptible to fluoroquinolone mutagenicity.
The researchers used the alpha-tocopherol form of vitamin E in their research.
“The antimutagenicity of alpha-tocopherol Vitamin C against norfloxacin-induced mutation was evaluated on Salmonella bacteria.”
The study showed that vitamin E had profound effects against reactive oxygen species-induced mutagenicity of this antibiotic.
“Vitamin E induced a statistically significant reduction in the mutagenicity of norfloxacin.”
(Older studies showed that animals given supplemental vitamin E had healthier offspring down through the generations… something which inferred the antimutagenic effect of this nutrient.)
Though vitamin C is also an antioxidant, this research showed very little benefit in lowering mutagenicity.
“Vitamin C had no such effect.”
In fact, vitamin C can actually act to increase oxidation in certain contexts.
“The minimal antimutagenic effect of Vitamin C may have been because Vitamin C can act as a pro-oxidant rather than an antioxidant.”
Importantly, for people who feel they need to use fluoroquinolone antibiotics…
…vitamin E did not affect the antibiotic properties of the treatment.
“Neither of these vitamins altered the minimum inhibitory concentration for norfloxacin against 25 uropathogenic strains of Escherichia coli.”
The researchers recommend that vitamin E should be used in conjunction with these types of antibiotics.
But vitamin E has a wider use case against mutagenicity in general.
“These results suggest that Vitamin E is a potent antimutagen that would be worthwhile being used in conjunction with fluoroquinolone treatment.”
We come in contact with mutagens every day.
Even ultraviolet rays from the sun can cause mutations in certain situations.
Vitamin E is an often overlooked but extremely protective nutrient.
—-Important Message—-
This powerful form of vitamin E builds more healthy T cells and boosts immunity
The only way to recover from most viral illnesses is with your own body’s natural defenses…
And when your immune system is functioning properly…
You’ll be making the all-powerful T cells.
T cells exist to identify and kill invading pathogens or infected cells.
These T cells are even more important than antibodies.
T cells can hang around in the blood for years after an infection and become part of your immune system’s “long term memory.”
This means your immune system works smarter and faster when encountering similar viruses and illnesses.
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